Congratulations to Junior Arroyo! His first-author paper entitled Predictive model for laser-induced tissue necrosis with immunohistochemistry validation was accepted for publication in the newest SPIE journal, Biophotonics Discovery.
This work is the first to demonstrate a unified theoretical, computational, and experimental approach with quantitative immunohistochemistry (IHC) validation to determine laser safety for biological tissues other than skin or eyes. Although photoacoustic imaging has the potential to provide critical guidance in surgical interventions, its widespread use is challenged by the absence of applicable safety guidelines across diverse target tissues. Maximum permissible exposure (MPE) guidelines currently focus solely on skin and eyes. Results are promising to provide tissue-specific MPE guidelines to maintain healthy liver tissue during laser-based optical and photoacoustic surgeries and interventions. The presented approach and associated outcomes are promising for the introduction of tissue-specific safety guidelines for photoacoustic imaging and other optics-based imaging technologies that are designed to maximize signal-to-noise ratios while being designated as safe for patient use. In addition, the presented simulation framework and corresponding experimental protocols may be applied to other internal organs to achieve similar benefits.
Citation: Arroyo J, Sharma A, Zhang J, Bell MAL, Predictive model for laser-induced tissue necrosis with immunohistochemistry validation, Biophotonics Discovery 1(2):025003, 2024 [pdf]